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Research and development


New abdominal wall formation from a biological implant is a multi-step mechanism. During this process, metalloproteinases (MMps) which are involved in physiological wound healing allows the implant integration. MMPs are proteolytic enzymes synthesized during non-pathologic extracellular matrix (ECM) remodelling in order to degrade specifically ECM molecules.

They can also remodel biological implants to create a physiological abdominal wall.

However, an abnormal high level of MMPs can induce an unwanted fast implant degradation. In addition, on septic sites, proteases are produced by bacteria that further degrade ECM molecules, interfering with the physiological implant integration. Thus, the MMPs level plays a crucial role in the integration of the implant. To address this issue, we are working with a scientific committee to develop next generation of biomaterials that will help to treat complex pathologies where tissue and cellular engineering could meet unsatisfied medical needs.


The Scientific Committee of Meccellis Biotech is composed exclusively of surgeons’ specialists involved in our R&D programs.

Meccellis Biotech has also established a partnership with companies expert in collagen and absorbable biopolymers to participe in its R&D projects.

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